Publications
Understanding the Complexity of Transcription Initiation in Prokaryotes
Review Article on Promoter Sequences
Promoter sequences are important genetic control elements. Through their interaction with RNA polymerase they determine transcription strength and specificity, thereby regulating the first step in gene expression. This article reviews the influence of promoter sequence on the mechanisms and kinetics of transcription initiation. This knowledge can be utilized in the development of a more rational approach to promoter engineering. It can help design more predictable, tuneable, and orthogonal promoter sequences, which is important in the context of regulation of gene expression and further, the development of robust microbial cell factories.
You can read the full article here:
Cara Deal, Lien De Wannemaeker and Marjan De Mey
March 2024
credit: Deal et al.
credit: Deal et al.